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Weight loss therapies produce improvements in Type 2 Diabetes control
Weight loss is an important therapeutic objective for individuals with type 2 diabetes. Short-term studies
have demonstrated that weight loss in overweight or obese type 2 diabetic subjects is associated with
decreased insulin resistance, improved measures of glycemic control, reduced lipemia, and reduced blood
pressure.
Other approaches to weight loss that might be effective in type 2 diabetic subjects include use of meal
replacements, repetitive use of low-calorie diets, and weight loss medications.
In a study conducted at University of Minnesota General Clinical Research Center, a total of 61 subjects
were enrolled and randomly assigned to treatment groups. Patients underwent a history and physical
examination, screening laboratory tests, and an electrocardiogram. Eligibility criteria were age 30–70 years,
diagnosis of type 2 diabetes with HbA1c between 7.0 and 10.0%, BMI between 27 and 50 kg/m2, stable
weight for the previous 3 months, and constant doses of any oral diabetes, hypertension, and lipid medications
for at least 1 month.
The purpose of our study was to combine several weight loss treatments in an effort to produce and maintain
substantial weight loss over an extended period in subjects with type 2 diabetes.
The study conclusion was that overweight or obese people with type 2 diabetes receiving a weight loss
intervention that combined intermittent low-calorie diets, daily meal replacements, and the medication sibutramine
achieved and maintained significant weight loss over a 2-year period. This was accompanied by improvement
in diabetes control. The intervention used was simple and easy for subjects to understand and implement.
The cost of the program was about $6 per day, from which the cost of usual meals and snacks that were omitted
(two to six per day) should be subtracted.
The study data suggest that weight loss at 2 years of 4–5 kg (~4% of initial body weight) for people with type 2
diabetes can produce improvements in diabetes control that are likely to be clinically significant.
NOTE: The Information on this site is provided for information only,
and is not meant to substitute for the advice of your own physician or other medical professional.
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